PHILADELPHIA (AP) — Religion and science can combine to create some thorny questions: Does God exist outside the human mind, or is God a creation of our brains? Why do we have faith in things that we cannot prove, whether it's the afterlife or UFOs?

The new Center for Spirituality and the Mind at the University of Pennsylvania is using brain imaging technology to examine such questions as well as to investigate how spiritual and secular beliefs affect our health and behavior.

"Very few are looking at spirituality from a neurological side, from the brain-mind side," said Andrew Newberg, director of the center. "We have a fairly unique focus."

Newberg, a doctor of nuclear medicine and an assistant professor at Penn, also has coauthored three books on the science-spirituality relationship.

The center is not a bricks-and-mortar structure but a multidisciplinary team of Penn researchers exploring the relationship between the brain and spirituality from biological, psychological, social and ideological viewpoints. Begun in April 2006, it is bringing together some 20 experts from fields including medicine, pastoral care, religious studies, social work and bioethics.

"The brain is a believing machine because it has to be," Newberg said. "Beliefs affect every part of our lives. They make us who we are. They are the essence of our being."

Words such as spirituality and belief don't necessarily mean religious faith, Newberg said. For example, enlightenment can come to some people from artistic expression, nonreligious meditation, watching a beautiful sunset or listening to stirring music.

"Atheists have belief systems, too," Newberg said.

In one study, Newberg and colleagues used imaging technology to look at the brains of Pentecostal Christians speaking in tongues - known scientifically as glossolalia - then looked at their brains when they were singing gospel music. They found that those practicing glossolalia showed decreased activity in the brain's language center compared with the singing group.

The imaging results are suggestive of people's description that they do not have control of their own speech when speaking in tongues. Newberg said scientists believe speech is taken over by another part of the brain during glossolalia but did not find it during the study.

Other recent studies looked at the brains of Tibetan Buddhists in meditation and Franciscan nuns in prayer, then compared the results to their baseline brain activity levels.

Among other changes, both groups showed decreased activity in the parts of the brain that have to do with sense of self and spatial orientation - which suggests the description of oneness with God, of transcendence sometimes experienced in meditation or prayer.

Prayer and meditation also increase levels of dopamine, often referred to as the brain's pleasure hormone.

"The mind and the body are the flip side of the same coin," said Daniel Monti, head of Thomas Jefferson University Hospital's integrated medicine center. "Now we know some of the mechanisms by which that occurs, and it's becoming better and better understood."

The integrated medicine center treats patients with cancer, chronic pain and other ailments to work things like meditation and proper diet into their conventional therapy, Monti said. Such thinking seemed "fringy" to many people a decade ago, but it is becoming widely accepted by the medical community and patients, he said.

"Now there's the recognition that a truly effective treatment plan is not just giving a pill," he said. "We need to look at how to help a person adjust to a different lifestyle in addition to taking a pill."

Not many imaging studies have yet been done that look at changes in the brain's blood flow because technology has only within the last decade become sophisticated enough to study the brain in this way, Newberg said.

Specifically, cerebral blood flow in Newberg's studies is measured with single photon emission computed tomography, or SPECT. An increase in blood flow to certain parts of the brain means increased activity in those areas.

Newberg is studying how the brains of novice yoga practitioners change as they become more adept, and whether meditation can improve cognitive impairment in people with mild dementia or early Alzheimer's disease.

"The sky's the limit as far as the things we can study," he said.

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